When it comes to “going on a diet”, there are many well-trodden approaches. The traditional one, usually advocated by official policy makers, is to eat less and move more.

This advice is based on the first law of thermodynamics, a law that applies beautifully to internal combustion engines. Not so much human metabolism.

Nevertheless, the simplicity of this theory is so intuitively appealing that it has endured, and continues to endure, despite all the evidence to the contrary. It assumes that obesity is a disorder of energy imbalance: when calories-in exceed calories-out, there is an energy surplus that the body stores as fat.

“The ancient prescription of Hippocrates (400 BC) that the obese should eat less and exercise more continues nowadays to be a widespread approach for weight management despite its well-documented failures” (Dulloo et al 2012)

Perhaps you’ve already been there. Perhaps you already know that reducing the amount of food you eat starts well and ends badly. But you keep doing it anyway.

Don’t be too hard on yourselves, you regressors: counting calories is what you have been instructed to do, and what you have done, for longer than you care to remember, to little or no effect. Or rather, to great effect — at first. You reduce your calorie intake substantially, and quickly lose weight. Marvellous! You’re hungry, pretty much all the time, but the system’s working and you’ve got the willpower.

But soon enough your weight reaches that inevitable plateau. What’s more, your hunger is now raging, gnawing at both your stomach and your resolve.

You can only keep this up for so long, as every hard-boiled dieter will concur. You really do have to get off this treadmill.

Numerous studies have concluded that dieting is associated with long term weight gain. This phenomenon has even been given a scientific name: fat overshooting.

“The long-term result of dieting thus may paradoxically be the opposite of the desired goal” (Pietiläinen et al).

This apparent paradox is attributed to a decrease in resting energy expenditure and “adaptive thermogenesis”, as the body (the thyroid gland) adjusts its metabolic rate to match the reduction in calorie intake.
这种矛盾归因于静息能量消耗的减少和 “代谢的适应性 ”,因为身体(甲状腺)会调节身体的代谢率来适应卡路里摄入量的减少。

It doesn’t have to be like this. The long-term solution is easier, more effective and evidence based. It involves these three principles:

  1. When you cut out unnecessary carbohydrates, you burn body fat
  2. When you eat fat, you burn fat.
  3. When you eat protein, you stay full for much longer.

And so to the science.

Cutting out carbs

A low carbohydrate diet works because it reduces insulin secretion and stimulates the release of fat from storage.

That’s certainly true of insulin. Without this hormone you’re either dead or diabetic, but too much can make you fat and sick.

Insulin is the great multi-tasker, performing numerous important functions in the body. But in terms of weight management it has three major roles, as explained below.

First, insulin regulates blood sugar. Insulin is released by the pancreas when food enters the stomach, and nothing stimulates this hormone quite like carbohydrate. Carbohydrates include cereals and other starchy grains, bread, pasta, pastries, potatoes, and sweet and savoury snacks.

Eat carbohydrates and your digestive system will get to work, breaking them down into smaller molecules of glucose and then transporting those molecules through the gut lining into the bloodstream. The more carbohydrate you eat, the more glucose enters the blood.

This glucose, or sugar, needs to be tightly regulated. Too much and you are in potential danger. You have only (or should have only) around a teaspoon-worth of sugar coursing through your blood vessels at any given time.

This is where insulin comes in. It takes surplus glucose and sends it off for storage in your muscles and liver, where it becomes known as glycogen. When these depositories are full — and they have limited storage capacity — off goes that surplus glucose to your adipose tissue, aka body fat.

It’s the horrid inevitability of eating lots of carbs.

Thus, the second main role of insulin concerns fat storage. You only have room for around 2,000 calories-worth of glycogen in your muscles and liver, but the storage capacity of your adipose tissue is prodigious.

The third role of insulin is to block the flow of fat out of adipose tissue. All that guff you have heard about carbohydrate being the body’s “preferred” fuel is utter nonsense. Your body will always burn carbohydrate first, not because it loves it more than anything else but because circulating glucose is potentially lethal if it is not dealt with immediately.

If you continue to eat lots of carbohydrates, your fat stores will remain locked away. You won’t burn your stored fat because there’s no requirement to do so. When glucose from carbohydrate is not available, your body is only too happy to burn fat instead.

Eating fat to burn fat

For years, you’ve been told that in order to burn fat you have to avoid fat. It seems logical, so you have sacrificed flavour — because that’s what fat provides — to achieve your weight loss goal. You’ve even convinced yourself that those fat-free options are delicious, despite their disappointing aftertaste.

No gain without pain, right? Wrong — because if you want to burn fat, it is essential that you eat fat. Your goal is to burn the surplus fat that sits in your adipose tissue. Surplus energy is there to be drawn on when necessary. The trick is to make it necessary.

When your diet consists predominantly of fat (and protein) with very low carbohydrate, you switch from burning glucose to burning fatty acids and ketones, made from your body fat. That is why a low carbohydrate, high fat diet is sometimes referred to as a ketogenic diet.

Studies reveal that in the short term, there is no significant difference in the efficacy of a low carbohydrate diet or low-calorie diet. It’s in the long-term that the ketogenic diet comes into its own, and emerges as the superior system.

A systematic review investigated whether a very low carbohydrate ketogenic diet achieved better weight loss in the long term (and had better effects on cardiovascular health) than a low-fat diet. The researchers trawled through thirteen, high quality studies that had a duration period of at least 12 months. They found that those on the high fat diet achieved the greatest weight loss in the long term.

What constitutes a low-carbohydrate diet? There is no official definition, but less than 50g/day is generally accepted as low carbohdyrate. Less than 30g/day is considered a very low carbohydrate diet.

Eating more protein

It is every dieter’s dream to have an appetite that is totally and painlessly under control. Welcome to protein.

A higher protein diet by-passes the pain of weight loss. It not only keeps your appetite satisfied for longer, it promotes good health and vitality too.

There are two extraordinary ways in which it does this.

Protein Magics Away Appetite

Protein is more filling than fat, despite containing fewer calories per gram. In studies, a diet consisting of 30% protein has been found to markedly increase fullness, and to lead to less desire to eat.

How does protein do this? The answer lies in its ability to influence certain hormones that regulate appetite. One of these hormones is ghrelin.

Ghrelin is secreted in the stomach and stimulates appetite by acting as a hunger signal to the brain. Therefore, as you’d expect, levels of ghrelin rise when you reduce your calorie intake.

Protein suppresses concentrations of this hormone once you have finished eating, and for prolonged periods thereafter.

“Higher protein weight-loss diets have led to beneficial reductions in body weight, fat mass, and food intake, while preserving lean body mass, and improving satiety in overweight and/or obese individuals. Because of these benefits, higher protein diets are potentially a preferable dietary strategy in combating obesity than traditional reduced energy diets.”
Protein also increases levels of two key hormones that work in opposition to ghrelin, by suppressing hunger: polypeptide YY (PYY) and cholecystokinin (CCK).

PYY is secreted along the digestive tract; levels increase after eating, and decrease during fasting.

CCK is stimulated by both protein and fat, and makes you feel full by slowing down the rate at which food passes out of the stomach (‘gastric emptying’ is the terminology). PYY can have a pronounced effect on the desire to eat.

CCK has been the subject of some intense research over the last thirty years, mainly because of its influence on the gut-brain connection. It is found throughout the small intestine, and is released after eating. In the same way that ghrelin can increase appetite, CCK induces the feeling of fullness.
在过去的30年中, 胆囊收缩素一直是深入研究的主题,这主要是由于胆囊收缩素对肠-脑连接的影响。它遍布整个小肠,在进食后释放。和胃饥饿素可以增加食欲一样,胆囊收缩素可以引发饱腹感。

Protein burns fat faster

A high protein diet not only promotes appetite control, it speeds up fat burning. It does this by increasing your resting metabolic rate. What’s more, this effect is immediate, which is terrific because you want to lose weight in the here and now, not on another time and space continuum.

When a group of 130 men and women aged 40–56 were given either a high protein, low carbohydrate diet, or a low protein, high carbohydrate diet, for four months, those in the high protein group lost 22% more fat mass than the high carbohydrate group, even though these two groups consumed the same number of calories throughout. As the researchers conclude:

“positive outcomes associated with increased dietary protein are thought to be due primarily to lower energy intake associated with increased satiety, reduced energy efficiency and/or increased thermogenesis, positive effects on body composition, specifically lean muscle mass, and enhanced glycemic control.”

What protein?

The best quality sources of protein are meat, fish, seafood, eggs and cheese. The best plant protein for vegetarians is nuts, such as cashews, hazelnuts, walnuts and pecans, as they are a combination of fat and protein. The problem with other plant-based sources of protein is that they almost always contain high amounts of carbohydrate, which is what you are trying to avoid.

Take quinoa, often suggested as an ideal source of vegetarian protein. The truth is it contains only 14% protein: the rest is mainly carbohydrate.

When you combine protein with high amounts of fat, and as little carbohydrate as possible, weight loss is accelerated, and feels effortless.

That is the fundamental science of successful, long-term weight loss. But to complete the package, there’s one more important consideration. The timing of your meals, and when and how you sleep are both crucial elements of fat burning metabolism. You need to make sure you are aligned with your body clock — aka circadian rhythm - in order to trigger the hormones that stimulate fat burning.